ea0090p602 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023
Cerda Alexis
, Yuri Gabriela
, Villagran Isidora
, Muller Andrea
, Foerster Claudia
, Ormazabal Paulina
Background: Obesity is strongly associated with insulin resistance (IR). IR at the molecular level may be defined as a diminished activation of PI3K/Akt signaling and its related molecules (IRS-1/Akt/AS160) as well as reduced glucose uptake. Subjects with obesity have elevated plasma levels of saturated fatty acids, such as palmitic acid (PA), which triggers insulin signaling disruption in vivo and in vitro. Oregano (Origanum vulgare L.) is a plant u...